The recommended dose is 0.66 mg/kg of body weight administered once weekly by subcutaneous injection, on the same day each week, at any time of the day
The day of the weekly administration can be changed if necessary as long as the time between the 2 doses is at least 3 days. If more than 3 days (>72 hours) have passed, skip the missed dose and take your next dose on the regularly scheduled day
NGENLA should be given subcutaneously in the abdomen, thighs, buttocks, or rear upper arms. The site of injection should be rotated weekly
If more than 1 injection is required to deliver a complete dose, each injection should be administered at a different injection site
Visually inspect for particulate matter and discoloration prior to administration, whenever solution and container permit. If flakes, particles, or discoloration are observed, do not use the pen. Do not shake
Please see full Instructions for Use for detailed steps
- Instruct patients to read the NGENLA Instructions for Use in full before using their pen
- A How to Use NGENLA Placemat is also included in the Patient Starter Kit to guide patients through the administration process
If setting up the first use of a new pen:
Turn the dose knob to 1.0 for the 60-mg pen; for the 24-mg pen, set the dose knob to 0.4. If the knob goes too far, it can be turned back
Hold the pen with the needle pointing up. Tap the cartridge holder gently to float any air bubbles to the top
- Press the injection button until it cannot go any further and you see “0” in the dose window. If liquid appears at the needle tip, prepare the injection
Getting ready
- Instruct patients/caregivers to always wash hands with soap and dry well before handling a pen
Use the pen straight from the refrigerator or leave it at room temperature for up to 30 minutes for a more comfortable injection
- Check the expiration date on the pen label. Do not use if the expiration date has passed
- Injection should be given in the abdomen, front of the upper thighs, buttocks, or back of the upper arms
Select a different site for each injection
Do not inject into bony areas; areas that are bruised, red, sore, or hard; and areas that have scars or skin conditions
- Clean the injection site with an alcohol swab and let dry
 | Letting the injection site dry completely before dosing may help provide a more comfortable injection |
Prepare the injection
Pull off the pen cap and check that the medicine is colorless to slightly light yellow and is free of flakes or particles
- Do not inject the medicine if it is cloudy or dark yellow
Attach the needle by gently pushing and then screwing it onto the pen
Pull off the outer needle cover
Pull off the inner needle cap and dispose of it in a sharps container
- Turn the knob to set the dose
- For the 24-mg/1.2-mL pen, the dose knob turns 0.2 mg at a time
- For the 60-mg/1.2-mL pen, the dose knob turns 0.5 mg at a time
- Check the dose window to make sure the correct dose has been set
- Hold the pen so the numbers in the dose window can be seen
- Insert the needle straight into the skin
- Press the injection button until it cannot go down any further and hold for 10 seconds
- Counting to 10 will allow the full dose of medicine to be given
- After counting to 10, let go of the injection button and slowly remove the pen from the injection site by pulling the needle straight out
Unscrew the needle and dispose of it in a sharps container. Never reuse needles
refrigerator between uses
Step-by-step video tutorial on how to prepare and give an injection with the NGENLA prefilled pen. You can also download the complete Instructions for Use here.
NGENLA has 8 years of clinical data2